PCI-34051 - HDAC8 Inhibitor. CAS# 950762-95-5 B3i SGC707 was used at 5-10

SGC707 was used at 5-10 µM final concentration in various in vitro assays

Russell JL

22(17):5396-404

11(2):427-38

Anacetrapib loweres PCSK9 mRNA level to 60% of control and LDLR mRNA level to 67% of control

PCI-34051 - HDAC8 Inhibitor. CAS# 950762-95-5 B3i SGC707 was used at 5-10PCI 34051, CAS No. 950762 95 5, is a potent and selective inhibitor of histone deacetylase 8 (HDAC8) with an IC50 ~10 nM. It displays >200 fold selectivity over other HDAC isoforms 1, 2, 3, 6 and 10. PCI 34051 has a unique mechanism of action involving PLCgamma1 activation and calcium induced apoptosis, and could offer benefits including a greater therapeutic index for treating T cell malignancies. PCI 34051 induces caspase dependent apoptosis in cell