SIS3 HCl - CAS# 521984-48-5 225 with an IC50 value of

with an IC50 value of 383 nM

Modulation of innate and adaptive immune responses by tofacitinib (CP-690

2*1H2/t11-

Molecular Weight: 369

This may lead to the induction of cell cycle arrest and apoptosis in susceptible tumor cells

SIS3 HCl - CAS# 521984-48-5 225 with an IC50 value ofSIS3 HCl, CAS No. 521984 48 5, a novel specific inhibitor of Smad3, inhibits TGF and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK p38, ERK, or PI3 kinase signaling pathways. Product information CAS Number: 521984 48 5 Molecular Weight: 489. 99 Formula: C28H28ClN3O3 Synonym: (E) SIS3 Chemical Name: (2E) 1 (6,7 dimethoxy 1,2,3,4 tetrahydroisoquinolin 2 yl) 3 {1 methyl 2 phenyl 1H pyrrolo[2,3 b]pyridin 3 yl}prop 2 en