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Addition of 20-100 nM Hesperadin leading to loss of phosphorylation of the mitogenic histone H3 at the Ser10 site
Smiles: CC1=NN=C2C(=CC(=NN12)C1=CC=C(C)C(=C1)NS(C)(=O)=O)NC(=O)OCC
InChi: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4
InChi: InChI=1S/C24H25N7O5/c1-14-10-15(2-4-25-14)23-27-18(13-35-23)22(33)26-17-11-19-20(28-21(17)31-5-3-16(32)12-31)29-24(36-19)30-6-8-34-9-7-30/h2
Solubility: DMSO 88 mg/mL (200
FM-479 11378 Addition of 20-100 nM HesperadinFM 479 is the negative control of FM 381 (HY 102046) and has no activity on JAK3 or other kinases. FM 381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM 381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600 fold selectivity over JAK1, JAK2 and TYK2, respectively. Product information CAS Number: 2226521 64 6 Molecular Weight: 442. 51 Formula: C25H26N6O2 Chemical Name: (2E) 2 cyano 3 (5 {3 cyclohexyl 10 methyl 3,