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is a selective KAT5 (Tip60) histone acetyltransferase inhibitor that inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response
Transpl Immunol
339(1):228-37
A Potent and Selective Inhibitor of Cdc42 GTPase
while XAV939 binds TNKS directly
BLU-9931 - CAS# 1538604-68-0 255 is a selective KAT5 (Tip60)BLU 9931, CAS No. 1538604 68 0, is a potent and irreversible small molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU 9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU 9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor
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