A-770041 vimopan monohydrate Matrine (Matridin-15-one) is an alkaloid

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus

Sweeney ZK

PubMed Central PMCID: PMC3263969

Chemical Name: (3Z

InChi: InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H

A-770041 vimopan monohydrate Matrine (Matridin-15-one) is an alkaloidA 770041 is a potent ans selective LCK inhibitor. Concanavalin A stimulated IL 2 production in whole blood is inhibited by A 770041 with an EC50 of approximately 80 nM. A 770041 is orally bioavailable (F = 34. 1 + 7. 2% at 10 mg kg) and has a t(1 2) of 4. 1 + 0. 1 h. Concanavalin A induced IL 2 production in vivo is inhibited by oral administration of A 770041 (in vivo EC50 = 78 + 28 nM). A 770041 reverses paclitaxel and doxorubicin resistance in