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Cefoselis hydrochloride penetrates the blood-brain barrier
CAS Number: 1092351-67-1
Thromb Res
ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17
InChi: InChI=1S/C33H40O15/c1-13(2)5-10-17-18(35)11-19(36)21-24(39)30(28(46-29(17)21)15-6-8-16(43-4)9-7-15)47-33-31(26(41)22(37)14(3)44-33)48-32-27(42)25(40)23(38)20(12-34)45-32/h5-9
RN486 Size:Solid 10 mg Cefoselis hydrochloride penetrates the blood-brainRN486 is a Bruton's tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell based assays in multiple cell types, blocking Fc receptor cross linking induced degranulation in mast cells (IC(50) = 2. 9 nM), Fc receptor engagement mediated tumor necrosis factor production in monocytes (IC(50) = 7. 0 nM), and B cell antigen receptor induced expression of an
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