EZH2-IN-4 7361 3-dihydro-1H-indol-2-yl]methoxy}-3-(tert-butylsulfanyl)-1-{[4-(5-methoxypyrimidin-2-yl)phenyl]methyl}-1H-indol-2-yl)-2

3-dihydro-1H-indol-2-yl]methoxy}-3-(tert-butylsulfanyl)-1-{[4-(5-methoxypyrimidin-2-yl)phenyl]methyl}-1H-indol-2-yl)-2

Chemical Name: N-[2-(2-bromoethoxy)ethyl]propanamide

5]undecan-2-yl)methyl)benzo[d]oxazole-4-carboxylate

4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2

2014 Oct 1

EZH2-IN-4 7361 3-dihydro-1H-indol-2-yl]methoxy}-3-(tert-butylsulfanyl)-1-{[4-(5-methoxypyrimidin-2-yl)phenyl]methyl}-1H-indol-2-yl)-2EZH2 IN 4 is an orally active, potent EZH2 inhibitor with IC50s of 0. 923 nM and 2. 65 nM against wild type (WT) 5 membered (5 mer) EZH2 and mutant 5 mer EZH2, respectively. EZH2 IN 4 has anti cancer activity. Product information CAS Number: 2088132 99 2 Molecular Weight: 511. 72 Formula: C29H41N3O3S Chemical Name: 7 ((4, 6 dimethyl 2 oxo 1, 2 dihydropyridin 3 yl)methyl) 2 ((R) 1 ((1r, 4R) 4 (3 methoxyazetidin 1 yl)cyclohexyl)ethyl) 3 methyl 4, 5, 6,