Z-VDVAD-FMK 21843 COCCOCCOCCN(CC(C)(C)S)C1=CC(COC2=CC3N[C@H]([C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)S([O-])(=O)=O)=CC(COC2=CC3NC[C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)=C1

COCCOCCOCCN(CC(C)(C)S)C1=CC(COC2=CC3N[C@H]([C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)S([O-])(=O)=O)=CC(COC2=CC3NC[C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)=C1

trans-24 is a potent and specific Eg5 inhibitor with an IC50 of 0

Many vendors confused them

InChi: InChI=1S/C7H16N4O2

Smiles: CN1CCN(CC2C=CC(=CC=2)C2=CN(C3CCC(O)CC3)C3=NC(NCCCC)=NC=C23)CC1

Z-VDVAD-FMK 21843 COCCOCCOCCN(CC(C)(C)S)C1=CC(COC2=CC3N[C@H]([C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)S([O-])(=O)=O)=CC(COC2=CC3NC[C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)=C1Jurkat T lymphocytes treated with an irreversible caspase 2 inhibitor, benzyloxycarbonyl Val Asp(OMe) Val Ala Asp(OMe) fluoromethyl ketone (Z VDVAD FMK), or stably transfected with pro caspase 2 antisense (Casp 2 AS) are refractory to cytochrome c release stimulated by etoposide1. When etoposide induced activation of pro caspase 2 is subverted by Z VDVAD FMK or stable transfection of pro caspase 2 antisense, cytochrome c release and other