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InChiKey: AXRUEPFPTQYHQD-UHFFFAOYSA-N
and lowers intraocular-pressure (IOP)
InChi: InChI=1S/C24H32O6/c1-22-9-7-15(25)11-14(22)4-5-17-19(22)20(27)21(28)23(2)16(8-10-24(17
1126/science
Pre-treatment with 2 and 6 μM Xanthorrhizol reduces tumor multiplicity to 6
BDA-366 Size:Contact [email protected] for quotation InChiKey: AXRUEPFPTQYHQD-UHFFFAOYSA-NBDA 366 is a selective antagonist of BCL2 BH4 domain with Ki value of 3. 3 nM . BCL2 is an important anti apoptotic protein. BCL2 homology 4 (BH4) domain is required for its antiapoptotic function, thus acts as a promising anticancer target . BDA 366 is a selective BCL2 inhibitor. BDA 366 induced conformational change of BCL2 that exposed the BH3 domain, resulting in abrogation of its prosurvival function and conversion of BCL2 to a prodeath protein.
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