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28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20
Water: 100 mg/mL(169
Chemical Name: N-[(2S)-1-amino-3-(3
2-dimethylpropanoyl)oxy]benzenesulfonamido}phenyl)formamido]acetic acid sodium
InChiKey: LRAJHPGSGBRUJN-OMIVUECESA-N
NB-598 Hydrochloride alafenamide hemifumarate 28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20NB 598 is a potent competitive inhibitor of squalene epoxidase (SE). NB 598 suppresses triglyceride biosynthesis through the farnesol pathway. NB 598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB 598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB 598 suppressed the basolateral secretion of apolipoprotein (apo) B.
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