Isoginkgetin ker Conjugates 3 Chemical Name: (3R)-1-{2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzoyl}piperidin-3-ol

Chemical Name: (3R)-1-{2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzoyl}piperidin-3-ol

Smiles: CC(O)=C(C#N)C(=O)NC1=CC(Br)=CC=C1Br

InChi: InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H

CAS Number: 1355681-10-5

GSK2982772 is also able to reduce spontaneous production of cytokines (IL-1β and IL-6) in a concentration-dependent fashion from ulcerative colitis explant tissue in overnight incubations

Isoginkgetin ker Conjugates 3 Chemical Name: (3R)-1-{2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzoyl}piperidin-3-olIsoginkgetin is a MMP 9 inhibitor, also a Pre mRNA Splicing Inhibitor with IC 50 of 30 uM. target : MMP 9 , Pre mRNA Splicing IC 50: 30 u M (Pre mRNA Splicing)In vitro: Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin is also quite effective in inhibiting the activities of Akt and MMP 9 in MDA MB 231 breast carcinomas and B16F10 melanoma. Isoginkgetin treatment result in marked decrease in invasion of these cells.