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Yoshimura C
SKPin C1 was used at 10 µM final concentration in various in vitro assays
Formula: C22H25N3O4
is a pan-Janus-activated kinase inhibitor
InChi: InChI=1S/C17H16N8/c1-2-10(1)13-8-16(25-24-13)22-15-5-6-18-17(23-15)21-11-3-4-12-14(7-11)20-9-19-12/h3-10H
SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 size:10 mg solid Yoshimura CSW033291, CAS No. 459147 39 8, is a highly potent and selective inhibitor of 15 PGDH enzyme with IC50 1. 5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15 PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3. 5 fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue
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