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NCB-0846 has anti-Wnt activity
Smiles: C[C@]12O[C@H](C[C@]1(O)C(=O)OC)N1C3C4=C(C5CNC(=O)C=5C=3C3=CC=CC=C13)C1=CC=CC=C1N24
InChi: InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4
PND-1186 treatment caused downregulation of FAK Tyr-397 phosphorylation and cyclin D1 amount (Supplementary Figures S8c and d) and increased the expression of both p21 and cleaved caspase-3 at 48 h (Figure 8b)
Objective responses were not observed for the solid tumor or ALL xenografts
Geniposidic acid - CAS# 27741-01-1 Catalog No.:M9895-10 NCB-0846 has anti-Wnt activityGeniposidic acid is a biochemical that promotes collagen synthesis, increases osteoblast proliferation, and inhibits survival of Kalotermes flavicollis and Crematogaster scutellaris. Product information CAS Number: 27741 01 1 Molecular Weight: 374. 34 Formula: C16H22O10 Chemical Name: (1S,4aS,7aS) 7 (hydroxymethyl) 1 {[(2S,3R,4S,5S,6R) 3,4,5 trihydroxy 6 (hydroxymethyl)oxan 2 yl]oxy} 1H,4aH,5H,7aH cyclopenta[c]pyran 4 carboxylic acid Smiles:
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