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InChi: InChI=1S/C9H10O4/c1-12-8-4-3-6(5-7(8)10)9(11)13-2/h3-5
Parkinson’s disease
Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation
4-Vinylphenol (50
0]oct-2-en-3-yl]methyl}-1-{2-[(2-chloro-3
CFI-400945 rexol InChi: InChI=1S/C9H10O4/c1-12-8-4-3-6(5-7(8)10)9(11)13-2/h3-5CFI 400945 is an orally active, potent and selective inhibitor of polo like kinase 4. Polo like kinase 4 (PLK4), a unique member of the Polo like family of kinases, shares little homology with other polo like kinases. PLK4 plays an essential role in centriole duplication. Overexpression of PLK4 overrides the centriole licensing mechanism and results in centriole amplification with multiple procentrioles forming around each parental centriole.
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