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Amitriptyline modulated Ca(2+) signaling and induced Ca(2+)-independent cell viability in human osteosarcoma cells
5-3(6)1-2-4(7)8/h2-11H
9a-octahydro-5
United Arab Emirates) (2010)
InChi: InChI=1S/C26H28N8O/c1-16-23-24(31-26(29-16)30-19-14-28-34(15-19)20-8-10-27-11-9-20)32(2)22-13-18-7-5-4-6-17(18)12-21(22)25(35)33(23)3/h4-7
Irinotecan hydrochloride trihydrate Catalog No.:M7807-2 Amitriptyline modulated Ca(2+) signaling andIrinotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7 ethyl 10 hydroxy camptothecin (SN 38) by a carboxylesterase converting enzyme. One thousand fold more potent than its parent compound irinotecan, SN 38 inhibits topoisomerase I activity by
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