AC710 - CAS# 1351522-04-7 aempferol Mahadevan D

Mahadevan D

CDK8/19i maintains pluripotency of mouse PSCs in culture

but it is now rarely employed because of its higher incidence of severe adverse effects

Smiles: OC1C(Br)=CC(=CC=1Br)C1=NOC(=N1)C(=O)NCC1C=CC(=CC=1)OC1C=CC=CC=1

InChi: InChI=1S/C20H23N3O3/c1-22(2)11-13-8-19(26-5)15(9-18(13)25-4)17-12-23(3)20(24)16-10-21-7-6-14(16)17/h6-10

AC710 - CAS# 1351522-04-7 aempferol Mahadevan DAC710 is a potent, orally active, and selective platelet derived growth factor receptor family kinase inhibitor with potential anticancer activity. Its IC50 values are 1. 2, 2, 7. 7 and 10. 5 nM for KIT, FLT3, PDGFR and CSF1R respectively; Kd = 1. 3 nM for PDGFR.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen induced arthritis. AC710 is now a