ASP3026 D17-109 4)5)34(22-35-51(42

4)5)34(22-35-51(42

is selective CB2 receptor agonist

Allopurinol is a structural isomer of hypoxanthine

The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants

InChiKey: GWHQHAUAXRMMOT-MBANBULQSA-N

ASP3026 D17-109 4)5)34(22-35-51(42ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI H2228, a human NSCLC tumor cell line endogenously expressing EML4 ALK variant 3 and that of 3T3 cells expressing EML4 ALK variant 1, 2 and 3. The plasma and tumor concentrations of ASP3026 in