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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
38)33(4)20-7-5-6-19(29)14-20/h5-9
indicative of replication fork collapse and double stranded DNA breaks
Hydrosaluric
2-di(isothiazol-5-yl)disulfane
AG-120 - CAS# 1448346-63-1 164 A chemical probe selectively inhibitsAG 120 (racemic), a racemic mixture of AG 120, CAS No. 1448346 63 1, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG 120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2 hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular