OT-R antagonist 1 798rterolane Smiles: C[C@]1(CCC[C@@]2(C)[C@H]1CC=C1C[C@](C)(CC[C@H]21)C=C)C(O)=O

Smiles: C[C@]1(CCC[C@@]2(C)[C@H]1CC=C1C[C@](C)(CC[C@H]21)C=C)C(O)=O

Chemical Name: 1-methyl-4-[6-(methylsulfanyl)-2-thiatricyclo[9

143621-35-6

Formula: C42H62O16

Solubility: DMSO : ≥ 113

OT-R antagonist 1 798rterolane Smiles: C[C@]1(CCC[C@@]2(C)[C@H]1CC=C1C[C@](C)(CC[C@H]21)C=C)C(O)=OOT R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT R antagonist. OT R antagonist 1 inhibits oxytocin evoked intracellular Ca2+ mobilization (IC50 = 8 nM). IC50 value: 8 nMTarget: oxytocin receptorin vitro: OT R antagonist 1 inhibitis IP3 Synthesis, rat OT R (IC50=0. 03 uM). OT R antagonist 1 inhibits phosphodiesterase IV with IC50 = 6. 1 M, a value about 300 fold higher than the affinity for OT R. OT R antagonist 1