Sertraline Hydrochloride IN-1 Smiles: C=CC1CS[C@@H]2[C@H](NC(=O)/C(=N\O)/C3=CSC(N)=N3)C(=O)N2C=1C(O)=O

Smiles: C=CC1CS[C@@H]2[C@H](NC(=O)/C(=N\O)/C3=CSC(N)=N3)C(=O)N2C=1C(O)=O

IC50=30 μM

robust PK/PD correlation and tumor growth inhibition (TGI) in a U87MG mouse xenograft model

CAS Number: 366789-02-8

654671-78-0 (Sitagliptin Phosphate)

Sertraline Hydrochloride IN-1 Smiles: C=CC1CS[C@@H]2[C@H](NC(=O)/C(=N\O)/C3=CSC(N)=N3)C(=O)N2C=1C(O)=OSertraline, also known as , is a selective serotonin uptake inhibitor that is used in the treatment of depression. Sertraline is primarily a serotonin reuptake inhibitor (SRI) with a binding affinity towards the serotonin transporter of Ki=2. 8 nM or in that range. Sertraline is also a dopamine reuptake inhibitor, (<50 nmol L). However, this is not considered a tight binding, and this action is only 10% of its potency as a monoamine reuptake