SBI-0206965 - Autophagy Kinase ULK1 Inhibitor. CAS# 1884220-36-3 0129 ALK4 (IC50 ~140 nM) and

ALK4 (IC50 ~140 nM) and ALK7

58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10

Self-renewal as a therapeutic target in human colorectal cancer

Pellock JM

GLPG0634 also inhibits Th1 differentiation with similar potencies of 1 μM or lower

SBI-0206965 - Autophagy Kinase ULK1 Inhibitor. CAS# 1884220-36-3 0129 ALK4 (IC50 ~140 nM) andSBI 0206965, CAS No. 1884220 36 3, is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI 0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1 mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI 0206965 greatly synergized with mechanistic target