TL13-12 idine isethionate Inhibitors of activin receptor-like kinase

Inhibitors of activin receptor-like kinase

SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR

Solubility: DMSO: 42 mg/mL(98

CAS Number: 1679333-73-3

β-arrestin-1 and β-arrestin-2 recruitment

TL13-12 idine isethionate Inhibitors of activin receptor-like kinaseTL13 12 is a potent and selective ALK PROTAC degrader and inhibits ALK activity with an IC50 value of 0. 69 nM. TL13 12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13. 5 nM, 5. 74 nM, 18. 4 nM, and 65 nM, respectively. TL13 12 is comprised of the conjugation of TAE684 (HY 10192) and the cereblon ligand of Pomalidomide (HY 10984). Product information CAS Number: 2229037 04 9