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InChiKey: NIBVEFRJDFVQLM-UNTBIKODSA-N
28(2):216-24
tolerability and clinical activity of VX-765
Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins
2-4H3/b14-12+/t18-/m1/s1
ZX-29 Size:Contact [email protected] for quotation InChiKey: NIBVEFRJDFVQLM-UNTBIKODSA-NZX 29 is a potent and selective ALK inhibitor with an IC50 of 2. 1 nM, 1. 3 nM and 3. 9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX 29 is inactive against EGFR. ZX 29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX 29 also induces protective autophagy and has antitumor effect. Product information CAS Number: 2254805 62 2 Molecular Weight: 518. 03 Formula:
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