SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-10S (2015) J Biol Chem

(2015) J Biol Chem

leading to decreased BMD and deterioration of bone properties in OVX rats

PubMed Central PMCID: PMC3966846

2019 Jul 30

ABT-888 dihydrochloride enhances apoptosis and autophagy in response to treatments that cause DNA breaks

SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-10S (2015) J Biol ChemSR9009, CAS No. 1379686 30 2, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~670 nM and REV ERB with EC50 ~800 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9009 alters circadian behavior and the circadian pattern of core clock