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AZ5104 display minimal off-target activity against other non-HER family kinases
The plantaris muscle was elevated and incised longitudinally
Smiles: COC1=CC=C(CCC(=O)NC2=NC3=CC=C(Cl)C=C3S2)C=C1OC
VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification
CAS Number: 486424-20-8
Siramesine Catalog No.:M10504-10 AZ5104 display minimal off-target activitySiramesine, also known as Lu 28 179, is a potent sigma 2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress. Product information CAS Number: 147817 50 3 Molecular Weight: 454. 58 Formula: C30H31FN2O Chemical Name: 1' {4 [1 (4 fluorophenyl)