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1627676-59-8
Therapeutic potential of AZD1480 for the treatment of human glioblastoma
1-6-2-4-7(5-3-6)11(8
Smiles: N#CC1C=C(N=CC=1)N1[C@@H](CCC1=O)C(=O)N([C@@H](C1=CC=CC=C1Cl)C(=O)NC1CC(F)(F)C1)C1=CC(F)=CN=C1
Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity
OTX015 - BET Inhibitor. CAS# 202590-98-5 size:2 mg solid 1627676-59-8OTX015, CAS No. 202590 98 5, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10 19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down regulation of c MYC expression, and show the synergistic anti proliferative effects in combination with ALK inhibitors in ALKpos
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