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In the rat mGlu4 PAM in vitro assay the EC50 of TCN238 (Compound 11) is 1 μM which is comparable to the human assay
InChiKey: HXHOBPVRRPCTLG-SETSBSEESA-N
11 and MOLM-13 acute leukemia cell lines with IC50s of 24
Chemical Name: 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile dimethanesulfonate
InChiKey: CZQHHVNHHHRRDU-UHFFFAOYSA-N
16-Epivoacarpine Size:Contact [email protected] for quotation In the rat mGlu4 PAM16 Epivoacarpine is a natural alkaloid isolated from Gelsemium elegans. Product information CAS Number: 114027 38 2 Molecular Weight: 368. 43 Formula: C21H24N2O4 Chemical Name: methyl (1R,12S,13R,14S,15E) 15 ethylidene 1 hydroxy 13 (hydroxymethyl) 3,17 diazapentacyclo[12. 3. 1. 0,. 0,. 0,]octadeca 2(10),4,6,8 tetraene 13 carboxylate Smiles: C C=C1 CN2[C@H]3CC4=C(NC5=CC=CC=C54)[C@]2(O)C[C@@H] 1[C@@]3(CO)C(=O)OC InChiKey: ZROBSNVANUBAJZ LWKNIGJSSA N
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