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Formula: C27H26N4O5S
BIX02189 also inhibited transcriptional activation of MEF2C
CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26
12 cells (EC50 ~ 4 nM) and RS4
Lersivirine retains activity against 80% of viruses with genotypes containing K103N as a single NNRTI mutation (versus 7% for efavirenz)
WYE-125132 Size:2mg solid Formula: C27H26N4O5SWYE 125132, also known as WYE 132, is a highly potent, ATP competitive, and specific mTOR kinase inhibitor (IC(50): 0. 19 + 0. 07 nmol L; >5, 000 fold selective versus PI3Ks). WYE 132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE 132 targeted P AKT(S473) and AKT function without significantly reducing the steady state level of the PI3K PDK1 activity biomarker P
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