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PubMed PMID: 21798735
It is a component of coal tar
MacMillan KS
also indicative of possible saturation of a clearance mechanism upon oral dosing
It comprises a ligand for Von Hippel Lindau (VHL) protein joined by a linker to a cereblon targeting ligand
Simvastatin acid ammonium tone Methyltransferase PubMed PMID: 21798735Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4 5 in the intestinal wall and liver (pKa=5. 5). Simvastatin ammonium reduces indoxyl sulfate mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. Product information CAS Number: 139893 43 9 Molecular Weight: 453. 61 Formula: C25H43NO6 Synonym: Tenivastatin ammonium Chemical Name:
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