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169939-94-0 (free base)
is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1
Abstract 1045
Glanzer JG
that is also capable of inhibiting various types of cancer cells by inhibiting the STAT3 activation pathway and human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9 by acting through the glucocorticoid receptor
GNE-317 O1138452 169939-94-0 (free base)GNE 317 is a potent and selective PI3K inhibitor with potential anticncer activity. GNE 317 targets the PI3K pathway and can cross the BloodBrain Barrier. GNE 317 was identified as having physicochemical properties predictive of low efflux by P gp and BCRP. Studies in transfected MDCK cells showed that GNE 317 was not a substrate of either transporter. GNE 317 markedly inhibited the PI3K pathway in mouse brain, causing 40% to 90% suppression of the
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