![LDE225 Diphosphate Catalog No.:M9943-10 Chemical Name: N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M9943_1621561061.gif?v=1621561063)
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Chemical Name: N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1
3D Matrigel Transwell invasion assays demonstrate that 10 μM HTH-01-015 markedly inhibits the invasiveness of U2OS cells in this assay
Solubility: DMSO: 13 mg/mL(27
8(3):e60827
Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits
LDE225 Diphosphate Catalog No.:M9943-10 Chemical Name: N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1Sonidegib, also known as, erismodegib, LDE225, NVP LDE225, is an orally bioavailable small molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh) ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. It was approved by the FDA for treating basal cell
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