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2-dimethylbutanoic acid
InChiKey: RGSVXQJPSWZXOP-UHFFFAOYSA-N
strongly decrease in HIF-1α levels at concentrations above 20 μM
whereas inhibits by HS-142-1
Formula: C12H14N2O6
Fipronil 19483 2-dimethylbutanoic acidFipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non desensitizing glutamate induced chloride currents in cockroach neurons (IC500s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1 2, CYP2B1 2, and CYP3A1 2 in isolated rat liver microsomes.
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