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CGS 21680 potently stimulates the formation of cAMP with an EC50 of 110 nM but is ineffective at inhibiting electrically stimulated dopamine release
STAT5-IN-2 is a STAT5 inhibitor
orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist
UBP-282 inhibits the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) with an IC50 value of 10
Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents
α-Guanidinoglutaric Acid rulline CGS 21680 potently stimulates theGuanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2. 69 M . In the brain, nitric oxide (NO), which is synthesized from L arginine (Arg) by NO synthase (NOS), acts as both an intra and an intercellular second messenger, and it may suppress convulsions . Guanidinoglutaric Acid (GGA) is a novel nitric oxide synthase inhibitor. GGA was increased in the cobalt induced epileptic focus tissue in the cerebral cortex of cats .
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