GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Barrett SD

Barrett SD

MLL have been observed in acute myeloid leukemia

1138549-36-6

GDC-0349 demonstrates pathway modulation and dose-dependent efficacy in mouse xenograft cancer models

Chemical Name: 3-(N-benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide

GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Barrett SDGNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53