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generation of ROS
11-dien-8-yl]methyl carbamate
Gandham VD
nonesterified fattyacids(33%–40%)
CAS Number: 1217448-46-8
HA14-1 - CAS# 65673-63-4 Catalog No.:M10927-2 generation of ROSHA14 1 is a potent Bcl 2 inhibitor with potential anticancer activity. HA14 1 induces apoptosis in various human cancer cells. HA14 1 suppressed NF kappaB activation through inhibition of phosphorylation and degradation of IkappaBalpha. This inhibition was correlated with suppression of NF kappaB dependent gene products (c myc, cyclin D1, cox 2, and IAP 1). Additionally, HA14 1 also markedly sustained TNF alpha mediated JNK activation. Product