XMD8-92 mterene 1-9H3/t22-

1-9H3/t22-

13-tetraene-10-carboxylate

O=C1CN2[C@@H]3CC1C[C@H]2CC(C3)OC(=O)C1=CNC2=CC=CC=C12

57% of viruses with genotypes containing Y181C as a single NNRTI mutation (43% for efavirenz)

(2013) J Am Chem Soc

XMD8-92 mterene 1-9H3/t22-XMD8 92 is an ERK5 BMK1 inhibitor and also BRD4 inhibitor. XMD8 92 inhibits pancreatic tumor xenograft growth via a DCLK1 dependent mechanism. XMD8 92 blocks cellular BMK1 activation and significantly suppresses tumor growth in lung and cervical tumor models and is well tolerated in animals. Product information CAS Number: 1234480 50 2 Molecular Weight: 474. 55 Formula: C26H30N6O3 Chemical Name: 5 {[2 ethoxy 4 (4 hydroxypiperidin 1 yl)phenyl]amino}