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Modulation of drug resistance transporters as a strategy for treating myelodysplastic syndrome
BRD-7552 increases PDX1 expression in mouse αTC cells but not βTC cells
BMS-56224701
Smiles: CC1CCN(CC1)C1=CC=C(C=C1C(F)(F)F)NC(=O)C1C=CC(CN2CCOCC2)=CC=1
Smiles: N#CCC1=CC=CC=C1C#CC1=CC(F)=C(CCC(O)=O)C=C1
GSK-923295 - CAS# 1088965-37-0 size:2mg solid Modulation of drug resistance transportersGSK 923295, CAS No. 1088965 37 0, also known as GSK 923295A, is a novel antimitotic inhibitor of centromere associated protein E (CENP E) with potential anticancer activity. GSK 923295A demonstrated significant antitumor activity against solid tumor models, inducing CRs in Ewing sarcoma, rhabdoid, and rhabdomyosarcoma xenografts. Clinical study showed that GSK 923295 had dose proportional pharmacokinetics and a low number of grade 3 or 4 adverse
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