JSH-23 - CAS# 749886-87-1 Catalog No.:M9452-10 selective and brain-penetrant inhibitor of

selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM

AB928 shows rescue of these gene expression changes

N'-(piperazine-1

Smiles: CN1C(C2C=CC(Cl)=CC=2)S(=O)(=O)CCC1=O

1446506-78-0

JSH-23 - CAS# 749886-87-1 Catalog No.:M9452-10 selective and brain-penetrant inhibitor ofJSH 23 is a nuclear factor kappa B (NF B) nuclear translocation inhibitor. JSH 23 inhibits LPS and cytokine induced nuclear translocation of the p65 subunit of NF kB as analyzed by EMSA and western blot. JSH 23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear