KU-60019 B018304 CAS Number: 1350547-65-7

CAS Number: 1350547-65-7

9(5):319-25

Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2

(2011) ACS Chem Biol

Cancer derived UMSCC38 cells

KU-60019 B018304 CAS Number: 1350547-65-7KU 60019 is a potent and selective ATM inhibitor. KU 60019 is 10 fold more effective than KU 55933 at blocking radiation induced phosphorylation of key ATM targets in human glioma cells. As expected, KU 60019 is a highly effective radiosensitizer of human glioma cells. KU 60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells