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ABT-199’s cell-killing effect is selective and mechanism dependent
stabilizing the complex between the enzyme and DNA
Epub 2014 Apr 3
InChi: InChI=1S/C20H20N4O2/c1-3-15-16(13-6-9-17(23-10-13)20(26)22-2)11-24-19(21)18(15)12-4-7-14(25)8-5-12/h4-11
Entrectinib potently blocks proliferation of Ba/F3-TEL-TRKB (IC50 of 2
SNIPER(ER)-87 Catalog No.:M7563-10 ABT-199’s cell-killing effect is selectiveSNIPER(ER) 87 is a potent and selective estrogen receptor (ER) Degrader (Specific and Nongenetic IAP dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER) 87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen binding moiety 4 hydroxytamoxifen (Cat. No. 3412). The product decreases ER levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER) 87 also reduces ER levels and inhibits
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