BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 for a broad range of

for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture

67(19):9472-81

angio-/lympho-genesis

Casein kinase II Inhibitor

NLG919 was used at 10 µM final concentration in various in vitro assays

BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 for a broad range ofBO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against