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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
(2011) Biochem Pharmacol
is a novel first in class
Smiles: O=C([C@@H](CC1C=C(C=CC=1)C(F)(F)F)NS(=O)(=O)C1=CC(F)=C2CNCCC2=C1)N1CCCC1
Chemical Name: 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2
EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 Dopamine neurons derived from humanEX 527, CAS No. 49843 98 3, is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 ~20 100 M). EX 527 has been used to investigate the relationship between SIRT1 mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1. Product information CAS Number:
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