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PRI-724 - CAS# 1422253-38-0 60101 3 μM and has anti-necroptosis

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Description

3 μM and has anti-necroptosis activity

Bonaventura et al (2019) High-potency ligands for DREADD imaging and activation in rodents and monkeys

2016 Aug 5

Exposure of cells to Midostaurin (PKC412) results in a dose-dependent increase in the G2/M phase of the cell cycle concomitant with increased polyploidy

0037 μg/mL

PRI-724 - CAS# 1422253-38-0 60101 3 μM and has anti-necroptosisPRI 724, CAS No. 1422253 38 0, also known as C 82 prodrug ICG 001 analog, is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI 724 specifically inhibits the recruiting of beta catenin with its coactivator CBP (the binding protein of the cAMP response element binding protein CREB); together with other transcription factors beta catenin CBP

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