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LY2784544 shows anti-proliferative activity in JAK2 V617F-driven cells with an IC50 of 68 nM
Discovery of potent competitive inhibitors of indoleamine 2
Aurora kinase A inhibitor Aurora A Inhibitor Idemonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells
which may result in drug-drug interactions
(S)-Tipifarnib is an inactive enantiomer of Tipifarnib to be used as a negative control
Novobiocin Sodium toside) LY2784544 shows anti-proliferative activity inNovobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Product information CAS Number: 1476 53 5 Molecular Weight: 634. 61 Formula: C31H35N2NaO11 Synonym: Albamycin Cathomycin Chemical Name: (3R,4S,5R,6R) 5 hydroxy 6 ({4 hydroxy 3 [4 hydroxy 3 (3 methylbut 2 en 1 yl)benzamido] 8 methyl 2 oxo 2H