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CVT-313 - CAS# 199986-75-9 0425 728865-23-4

SKU: 42556556857

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Description

728865-23-4

30 mg/kg results in measurable antitumor activity (%T/C=46%)

Bloedon LT

PubMed Central PMCID: PMC3500996

and leads to the stabilization of autophagy substrates

CVT-313 - CAS# 199986-75-9 0425 728865-23-4CVT 313, CAS No. 199986 75 9, is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation. CVT 313 has an IC50 of 0. 5 microM in vitro. Inhibition was competitive with respect to ATP (Ki = 95 nM), and selective CVT 313 had no effect on other, nonrelated ATP dependent serine threonine kinases. The growth of mouse, rat, and human cells in culture was also inhibited by CVT 313 with the IC50 for growth arrest ranging from 1. 25 to

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