LEO 39652 decyl Isothiocyanate CC[C@@H](N)CNC1=CC=NC(=N1)C1=CC(=CC=C1O)C1=CN(C)N=C1

CC[C@@H](N)CNC1=CC=NC(=N1)C1=CC(=CC=C1O)C1=CN(C)N=C1

625-40 μg/ml

Smiles: CC(C)(O)[C@H]1CC[C@](C)(O1)[C@H]1[C@@H](O)C[C@@]2(C)[C@@H]3C[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]4[C@]5(C[C@]53CC[C@@]21C)CC[C@H](O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)C4(C)C

LY3020371 (1-10 mg/kg

InChiKey: CQWXKASOCUAEOW-UHFFFAOYSA-N

LEO 39652 decyl Isothiocyanate CC[C@@H](N)CNC1=CC=NC(=N1)C1=CC(=CC=C1O)C1=CN(C)N=C1LEO 39652 is a dual soft PDE4 inhibitor with IC50s of 1. 2 nM, 1. 2 nM, 3. 0 nM and 3. 8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF with an IC50 value of 6. 0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) . Product information CAS Number: 1445656 91 6 Molecular Weight: 421. 45 Formula: C23H23N3O5 Chemical Name: 2 methylpropyl 1 [8 methoxy 5 (1 oxo 1,3 dihydro 2 benzofuran 5 yl)