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3-3 mg/kg in dogs)
11)72-50)71-47(62)24(3)4/h15-17
Formula: C25H20N4O2S2
TMB dihydrochloride (3
3-thiazole-5-carboxylic acid
Topotecan Catalog No.:M9751-2 3-3 mg/kg in dogs)Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I DNA covalent complexes, inhibiting religation of topoisomerase I mediated single strand DNA breaks and producing potentially lethal double strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline based alkaloid
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