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Churpek JE
(2015) Cell
PubMed PMID: 22736948
CAS Number: 152044-53-6
Int J Neuropsychopharmacol
CHIR-090 - CAS# 728865-23-4 0027 Churpek JECHIR 090, CAS No. 728865 23 4, is a very potent and selective LpxC inhibitor. CHIR 090 has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli. CHIR 090 is also a two step slow, tight binding inhibitor of E. coli LpxC with Ki = 4. 0 nM, Ki* = 0. 5 nM, k5 = 1. 9 min 1, and k6 = 0. 18 min 1. CHIR 090 at low nanomolar levels inhibits LpxC orthologues from diverse Gram negative pathogens, including P. aeruginosa, Neisseria
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