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Chemical Name: 4-amino-1-((2R
InChiKey: GACQNUHFDBEIQH-HNNXBMFYSA-N
Theodoulou NH
23(7):769-81
Chemical Name: (Z)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1
RA190 - Ubiquitin Receptor RPN13/ADRM1 Inhibitor. CAS# 1617495-03-0 60256 Chemical Name: 4-amino-1-((2RRA190, CAS No. 1617495 03 0, is a novel potent and selective inhibitor of proteasome Ubiquitin receptor RPN13 ADRM1. It covalently binds to the cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma (MM) lines, even those resistant to bortezomib, were sensitive to RA190 via endoplasmic reticulum stress related apoptosis.
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