MM-102 - WDR5-MLL1 Antagonist. CAS# 1417329-24-8 418 AK-7 was administered by intraperitoneal

AK-7 was administered by intraperitoneal injection to mice at 15-30 mg/kg/dose twice daily (formulation: 1

Quizartinib inhibits MV4-11 and A375 cells with IC50 of 0

Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells

Molecular Weight: 360

It was identified by an imaging-based high throughput screening in human MSCs

MM-102 - WDR5-MLL1 Antagonist. CAS# 1417329-24-8 418 AK-7 was administered by intraperitonealMM 102, CAS No. 1417329 24 8, is a highly potent and selective inhibitor of the MLL1 WDR5 interaction with an IC50 ~2. 9 nM binding affinity to WDR5. In the MLL1 AF9 transduced murine cells, MM 102 specifically reduces expression of two critical MLL1 target genes (HoxA9 and Meis 1), which are required for MLL1 mediated leukemogenesis. MM 102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.